Lupus Landmark Study is a research project aimed at understanding Systemic Lupus Erythematosus (SLE), a disease where the body’s immune system attacks its own tissues, by collecting data and samples from patients. Over 3,500 people with SLE in the US and Canada will join the study over five years. Participants will be placed in one of four groups based on their condition: New Onset (new diagnosis), Active Lupus Nephritis (affecting kidneys), Extra-Renal Lupus Flare (flare without kidney involvement), and Prevalent Cases (not fitting other groups). The study will collect data on participants' medical histories, social backgrounds, and environmental factors, plus biological samples like blood, urine, and saliva. These samples are essential for discovering more about genetics and other biological factors of lupus. To join, you must be at least 18, diagnosed with SLE, and able to consent.

• Study duration: 5 years
• Multiple visits may be required
• Samples taken: blood, urine, saliva, etc.