This research study examines how a new medicine called CagriSema affects heart and blood vessel diseases, like heart attacks and strokes. Participants will be randomly given either CagriSema or a placebo (a dummy medicine with no effect). The study medicine is injected once a week using a small needle in places like the stomach or upper arms. This study can last up to 4.5 years.

To join, you must be a man or woman who is at least 55 years old and have a body mass index (BMI) of 25 or more. You also need to have a history of cardiovascular disease (CVD) such as a past heart attack or stroke. For those with type 2 diabetes, you must have been diagnosed at least 180 days before joining and have specific blood sugar levels. There are some conditions that might exclude you from participating, like recent heart issues or planned surgeries.

• The study lasts up to 4.5 years.
• Participants will self-administer a weekly injection.
• Chance of receiving CagriSema or a placebo is equal.