This study is trying to understand why people with chronic kidney disease (CKD) have trouble exercising. CKD means your kidneys are not working well for a long time. The study also wants to see if exercise on a stationary bike or taking certain pills can help. These pills are called 6R-BH4 (Kuvan), histidine, and beta-alanine. 6R-BH4 is usually used for another disease but not for CKD. Histidine and beta-alanine are supplements used by athletes. The study will last between 6 to 14 weeks, and you'll exercise or stretch three times a week. Researchers will check your blood pressure and muscle health during exercise.
- Study Length: 6-14 weeks, 3 sessions per week.
- What's Involved: Exercise or stretching on a stationary bike.
- Who Can Join: People with CKD stage III or IV and those who do not exercise regularly.
This study is not for people with very severe kidney disease, serious heart problems, or those who cannot exercise on a bike. If you're interested, you should be willing to follow the study's rules.