This study looks at ways to prevent nerve damage, called peripheral neuropathy, caused by certain chemotherapy drugs like taxane. Peripheral neuropathy can make your arms and legs feel numb, tingly, or painful. The study tests three methods using a special device called the Paxman Limb Cryocompression System. This device uses cryocompression (cooling and squeezing), continuous compression (steady squeezing), or low cyclic compression (gentle, on-and-off squeezing) on your arms and legs. The goal is to see if these methods can stop the nerve problems from happening.

• Study Length: 12 weeks, with follow-ups up to 52 weeks.
• Visits: Regular visits for chemotherapy and device use.
• Risks: Possible skin changes or cold intolerance from the device.

To join, you should have a type of cancer called a solid tumor and be starting taxane chemotherapy soon. You cannot join if you have nerve issues already or certain blood or skin conditions. You must be 18 or older and able to fill out questionnaires. If you meet these criteria, you will be asked to give your consent to participate.