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Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

Comparing different pain treatments to see which works best.

Recruiting
All
Phase N/A

**Veterans Only**: This study is about finding the best ways to manage chronic low back pain (cLBP) without surgery or drugs. Chronic means it's been present for a long time, and low back pain is pain in the lower part of your back. The study has two steps. In the first, veterans will either keep getting regular care, use an online tool for managing pain called Pain EASE, or do special physical therapy that includes Pain EASE and exercises. If pain isn't much better, or if more treatment is wanted, the second step offers yoga, spinal manipulation therapy (SMT), or cognitive behavioral therapy (CBT). SMT involves adjusting your spine, and CBT is a type of talk therapy. The study lasts one year, with 2529 participants across 20 centers. It's designed to see which treatments help the most with pain interference, which is how much pain affects daily activities.

  • Participants will need to be available for in-person sessions and have internet access.
  • Participants will be monitored for one year to see how effective the treatments are over time.
  • The study focuses on non-drug, non-surgery options, which are generally low risk.
Study details
    Chronic Low Back Pain

NCT04142177

VA Office of Research and Development

17 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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