This study is checking how safe it is to stop a treatment called **anti-PD-1 therapy** early for people with advanced **melanoma**, a type of skin cancer that can't be removed by surgery. Anti-PD-1 therapy is a common treatment for this kind of melanoma. This trial uses special tests called **PET/CT scans** and **biopsies** to look for signs of cancer and decide if the treatment can be stopped early without harming the patient.

Key Points to Consider:

• The trial lasts up to 5 years, with regular check-ins even after treatment ends.
• Participants continue their usual treatment and may stop based on test results.
• Risks include potential side effects from stopping the treatment early.

Participants must have a type of melanoma that cannot be surgically removed and should be in good health otherwise. They will need to have regular PET/CT scans and possibly biopsies. The goal is to see if patients can safely stop therapy early, which might lessen side effects and treatment costs. Check eligibility and discuss any concerns with your doctor before joining.