Study Summary: This study aims to reduce the use of an antibiotic called vancomycin in children with suspected sepsis, a serious infection. Vancomycin is often used in hospitals for children, but its overuse can cause kidney problems. The study will take place in five Pediatric Intensive Care Units (PICUs) and will involve both doctors and patients in these units. The intervention includes a new guideline to help doctors decide when to use vancomycin, education for doctors, and feedback on how much vancomycin is being used.

Key Points:

• Duration: The study will last about 24 months.
• Participants: Patients in participating PICUs and clinicians working there.
• Benefits: The goal is to prevent kidney harm by reducing unnecessary vancomycin use.

The study will use data from Electronic Health Records (EHR) to track vancomycin use before and after the intervention. There are no specific exclusions for patients, but clinicians must be 18 or older and employed at a participating site. Volunteers and those with limited English may not participate.