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Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Exploring new treatment for high-grade upper urinary tract cancer.

Recruiting
18 years and older
All
Phase 2/3

This study is exploring if adding a drug called durvalumab to chemotherapy helps patients with a type of cancer in the urinary tract before they have surgery. Durvalumab is an immunotherapy drug that helps the body's immune system fight cancer. Chemotherapy uses strong medicines to kill cancer cells or stop them from spreading. The study aims to see if the combination treatment works better than chemotherapy alone.

  • The study lasts for several months, including treatment and follow-up visits every 3-6 months for up to 5 years.
  • Participants will receive either chemotherapy alone or with durvalumab, followed by surgery.
  • Various tests, like blood samples and scans, will be done throughout the study to monitor progress.

To join, you must be 18 or older, with specific medical criteria. You can't participate if you're pregnant, breastfeeding, or have certain other health issues. If you have questions or are interested, talk to your doctor about whether this study is right for you.

Study details
    Renal Pelvis and Ureter Urothelial Carcinoma

NCT04628767

National Cancer Institute (NCI)

28 June 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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