Arginine Therapy for Pain in Children with Sickle Cell Disease is a study to see if giving extra arginine, a building block of proteins found in foods, can help reduce pain in kids with sickle cell disease. This disease often causes painful episodes called vaso-occlusive events (VOE). When kids with sickle cell disease have low arginine levels, they might experience more pain. By increasing arginine levels, the study aims to lessen pain, reduce the need for pain medicines like morphine, and shorten hospital stays.

Key Points:

• The study is for kids aged 7-21 with specific types of sickle cell disease and requires medical care for pain.
• Participants will receive either a higher dose or continuous infusion of arginine to see if it helps with pain relief.
• Exclusion includes those with other types of sickle cell disease, certain health conditions, or recent use of similar treatments.