Image

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

Study testing safety and effects of new Alzheimer's treatment.

Recruiting
50-85 years
All
Phase 1/2

This study is about testing a new medicine called RO7126209 for people with early to moderate Alzheimer's disease (AD). Alzheimer's is a brain disease that affects memory and thinking skills. The medicine is given through an intravenous (IV) infusion, which means it goes directly into the bloodstream using a needle. The study aims to check if the medicine is safe and how well it works.

Participants need to have a positive amyloid PET scan, which is a brain scan that helps identify Alzheimer's. They also need someone, called a "study partner," to help them with the study. The study checks your health through tests like MRIs (a type of scan that takes pictures of the inside of your body) and lumbar punctures (a test that collects spinal fluid).

  • Participants will be in the study for a long time and will have to visit the study site multiple times.
  • They must not join any other study during this time or donate blood.
  • People with other major health problems may not be eligible to join.

Joining will help researchers learn more about Alzheimer's and develop better treatments.

Study details
    Alzheimers Disease

NCT04639050

Hoffmann-La Roche

15 February 2025

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Race
Ethnicity
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.