This study is for adults with major depressive disorder (MDD), a condition that makes people feel very sad and lose interest in things they used to enjoy. Researchers want to find out how well a new medicine called aticaprant works when added to the usual antidepressant treatments like SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors). Anhedonia is when people can't feel pleasure, and this study focuses on those with moderate to severe levels.
People can join this study if they are medically stable and have been taking an SSRI or SNRI for at least 6 weeks. They should not have responded well to other antidepressants they tried before. However, those who didn't respond to two or more treatments in their current episode or have certain other mental health disorders cannot join.
- This study involves taking aticaprant along with an existing antidepressant.
- Participants should have tried at least one antidepressant before without enough success.
- People with recent suicidal thoughts or behaviors will not be able to participate.