This clinical trial is exploring treatments for a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread or is advanced. Patients will be divided into three groups to test the effectiveness of different drug combinations, including a new drug called datopotamab deruxtecan (Dato-DXd), along with pembrolizumab and possibly chemotherapy.
The goal is to see how well these treatments work and how safe they are. The study will look at how long patients live without the cancer getting worse (Progression Free Survival or PFS) and overall survival (OS). Eligible patients must be adults who have not received prior treatment for their advanced cancer and have a specific type of tumor.
- Duration: The study includes a screening period, treatment phase, and follow-ups.
- Compensation: Not mentioned in the study details.
- Risks: Potential side effects from the drugs used in the study.