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A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

Exploring Verekitug's effects for severe asthma in adults.

Recruiting
18-80 years
All
Phase 2

This study tests a new medicine called verekitug (UPB-101) for adults with severe asthma. Asthma is a condition where it's hard to breathe because the airways in the lungs are narrowed. This study will check if verekitug helps reduce asthma attacks and how safe it is compared to a placebo (a harmless pill that looks like the real medicine). Participants will get shots under the skin (subcutaneously) of either verekitug or placebo. The study will have about 436 participants and will last up to 60 weeks, with some follow-ups for 16 weeks after the last dose.

  • Participants will visit the study center regularly over the 60-week period.
  • Participants will be randomly assigned to different dose groups.
  • Compensation for participation will be provided.
Study details
    Severe Asthma

NCT06196879

Upstream Bio Inc.

3 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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