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A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.

Studying Baxdrostat and Dapagliflozin for kidney health and high blood pressure.

Recruiting
18-130 years
All
Phase 3

This study looks at how well **baxdrostat** and **dapagliflozin** work together in adults with **CKD** (Chronic Kidney Disease) and **HTN** (High Blood Pressure). Baxdrostat is a new medicine being tested, while dapagliflozin is already used to help kidneys. The study starts with checking who can join, then a 4-week period where some people will only take dapagliflozin. After this, participants will take either baxdrostat with dapagliflozin or just dapagliflozin for 24 months. "Double-blind" means neither the doctors nor participants know who is getting which medicine. After 24 months, everyone takes only dapagliflozin for 6 weeks to check how their kidneys are doing. Visits to the study site happen at 2, 4, 8, and 16 weeks, then every 4 months.

  • This study is 24 months long, with regular check-ups.
  • Participants must be 18 or older with CKD and HTN.
  • Some medications are not allowed during the study.
Study details
    Chronic Kidney Disease and Hypertension

NCT06268873

AstraZeneca

17 May 2025

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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