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Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

Trial tests lower radiation doses after robotic surgery for HPV-related throat cancer.

Recruiting
18 years and older
All
Phase 2

This study is about using less radiation after surgery for HPV-positive throat cancer. HPV is a virus often linked to throat cancer. The usual treatment is robotic surgery followed by radiation. However, radiation can cause long-lasting side effects, like trouble swallowing. This study explores if using a lower radiation dose after surgery can help with swallowing and improve life quality.

Key Points:

  • Participants receive treatment over 3 weeks, with 15 radiation sessions if they test negative for HPV-related cancer cells after surgery.
  • The study checks participants' swallowing ability, cancer control, and survival rates over 2 years.
  • Participants must be 18 or older, have a certain health status, and agree to safety measures like using birth control.

Participants will have checkups at 3, 6, 12, 18, and 24 months after treatment ends. It's important to discuss with your doctor the possible benefits and risks, such as the lower risk of side effects but also the experimental nature of the treatment.

Study details
    Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
    Oropharyngeal HPV-Positive Squamous Cell Carcinoma

NCT05387915

Emory University

13 December 2024

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