Hidradenitis Suppurativa (HS) is a skin condition causing painful lumps. This study tests a drug, Povorcitinib, to see if it helps people with moderate to severe HS. For the first 12 weeks, some participants will receive a placebo, which is a fake treatment for comparison. Then, everyone can use the real drug for 42 weeks.

To join, you must have had HS for at least 3 months with specific types of lesions. You must have tried other treatments that didn't work or you couldn't take. You can't use certain soaps or antibiotics during the first 12 weeks, and you must agree to use contraception. Pregnant or breastfeeding women cannot join. If you have more than 20 fistulas (draining tunnels) or certain other medical conditions, you can't participate.

• Study lasts 54 weeks total, starting with 12 weeks placebo-controlled period.
• Visits will be required for screening and at the baseline, and throughout the study.
• Participants may receive compensation for their time and travel.

If interested, consider your health and ability to follow study guidelines.