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ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3)

Exploring new treatment options for specific ovarian cancer patients.

Recruiting
18-75 years
Female
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new treatment for ovarian cancer. It involves using a special type of immune cell therapy called **ADP-A2M4CD8** and a medicine called **nivolumab**. The study is for patients who have a certain type of protein in their cancer called **MAGE-A4** and a specific genetic marker called **HLA-A2**. **Nivolumab** is an immunotherapy, which helps the body's immune system fight cancer.

To be in the study, you must be between 18 and 75 years old and have a confirmed diagnosis of a certain type of ovarian cancer. You also need to meet specific health criteria. The study will involve several tests and procedures, including a process called **leukapheresis** to collect immune cells from your blood. You will receive treatment and be monitored over time to see how the cancer responds.

  • Study Length: Participation involves multiple visits and procedures over several months.
  • Compensation: Participants may receive compensation for their time and travel.
  • Risks: There are potential side effects from the treatments, such as immune reactions.
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Study details
    Ovarian Cancer

NCT05601752

Adaptimmune

12 October 2024

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