This study is about understanding if inflammation affects depression in people with HIV. HIV is a virus that affects the immune system. Inflammation is when the body is fighting something off, and it can make you feel sick. The study will last **10 weeks** and involve **60 male and female participants** with HIV and depression. Participants will take either an anti-inflammatory drug called baricitinib or a placebo (a pill that doesn’t do anything) for 10 weeks. This is a **double-blind study**, meaning neither the participants nor the researchers know who is taking the real medicine or the placebo. Participants will have lab tests, brain scans (fMRI), and optional spinal taps. The study will check if reducing inflammation helps with certain depression symptoms, like anhedonia (not feeling pleasure) and slow movements. **Key Points:** - The study lasts **10 weeks** and includes lab tests and brain scans. - Participants may receive a drug or a placebo without knowing which. - The study aims to see if reducing inflammation helps with depression in HIV patients.

Key Points:

• The study lasts 10 weeks and includes lab tests and brain scans.
• Participants may receive a drug or a placebo without knowing which.
• The study aims to see if reducing inflammation helps with depression in HIV patients.