Acute Ischemic Stroke (AIS) happens when blood flow to the brain is blocked by a clot. This study is testing the Penumbra System with Thunderbolt Aspiration Tubing to see how safe and effective it is for people with this condition. An ischemic stroke is when a large vessel in the brain gets blocked. If you're between 18 and 80 years old and have this kind of stroke, you might qualify for this study. Treatment should start within 8 hours of symptoms. The Penumbra System uses a tube to remove the clot. If you're eligible for thrombolytic therapy (a medicine to dissolve clots), it should be given within 3 hours of symptoms. Mechanical thrombectomy is a procedure to remove the clot. You can't join if you're pregnant or have conditions like severe vessel narrowing or if you're in another medical study.

• The study involves treatment within 8 hours of stroke symptoms.
• Participants should be aged 18 to 80 years.
• Informed consent is required for participation.