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Study of Tuvusertib (M1774) in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)

Trial of Tuvusertib with DNA or immune inhibitors for solid tumors.

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new treatment called tuvusertib to help people with certain advanced cancers. Tuvusertib is tested with another treatment, either a DNA Damage Response Inhibitor (which helps fix DNA errors in cells) or an Immune Checkpoint Inhibitor (which helps the immune system fight cancer). This study is open-label, meaning both doctors and participants know which treatments are given. Doctors want to find out how safe these treatments are and the best doses to use.

  • The study has different parts for different cancer types, like prostate and endometrial cancer.
  • Participants must have advanced cancer that doesn't respond to regular treatments.
  • This study involves multiple visits and tests to ensure safety and effectiveness.

Participants should have good overall health and a life expectancy of at least 3 months. They should not have other serious health conditions or new cancers. This study helps researchers learn how these treatments work together and find the best way to help people with these tough-to-treat cancers.

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Study details
    Metastatic or Locally Advanced Unresectable Solid Tumors

NCT05396833

EMD Serono Research & Development Institute, Inc.

12 July 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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