This study is testing a new medicine called lorundrostat to see if it helps lower blood pressure. Blood pressure is the force of blood pushing against the walls of your arteries. The study is for people who have high blood pressure that doesn't go down even when they take medicine. Lorundrostat works by stopping a hormone called aldosterone (it helps your body control blood pressure) from being made in your body. The study will happen in the United States at about 75-100 places.

Participants will first try a standard medicine for high blood pressure. Then, they will be randomly given lorundrostat or a placebo (a fake medicine) without knowing which one they get. After this, there is a time when participants stop taking the medicine to see how they do. People can also choose to continue the study by taking lorundrostat openly.

• The study lasts several months with multiple visits.
• Participants must be at least 18 and have high blood pressure.
• Possible risks include changes in blood minerals like potassium and sodium.