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Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

Assessing safety and effectiveness of a new HIV treatment plan for adults.

Recruiting
18 years and older
All
Phase 1/2

This study is testing a new treatment plan for people with HIV who started therapy early. It involves a combination of vaccines and medications aimed at controlling HIV without needing daily medicine. The vaccines use viruses (chimpanzee adenovirus and poxvirus) to help the immune system fight HIV better. The study also includes special antibodies that help block the virus and a medicine called vesatolimod, which boosts immune response. Participants will be randomly assigned to receive either the treatment or a placebo (a harmless pill) and will stop their usual HIV treatment at certain times to see if the new method works.

  • The study lasts up to 110 weeks (about 2 years), with four steps involving treatment and pauses in HIV medicine.
  • Participants must attend regular visits and follow specific guidelines, including temporarily stopping their regular HIV treatment.
  • Eligibility includes a certain weight and no recent use of certain vaccines or medications.
Study details
    HIV-1-infection

NCT06071767

National Institute of Allergy and Infectious Diseases (NIAID)

30 March 2025

Step 1 Get in touch with the nearest study center
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  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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