This study is testing two types of injections for knee osteoarthritis, a condition that causes pain and stiffness in the knee. One injection is called **MFat**, which uses a person’s own fat processed with a special system, and the other is a **saline** solution. Saline is just saltwater. The study will involve 173 participants and will happen at 20 locations in the United States. This is a *randomized and double-blinded* study, meaning participants will be randomly chosen to receive either MFat or saline, and neither they nor the doctors will know which one they received.

• The study lasts for several months, with multiple follow-up visits required.
• Participants must be adults, have knee osteoarthritis, and have tried other treatments without success.
• Participants must agree to stop certain medications and must not have certain health conditions.

It's important to be aware of the eligibility criteria and the commitment required. Participants will need to be able to travel for follow-up visits and stop using some pain medications before and during the study. Compensation details for participation are not mentioned, so be sure to inquire if this is a concern.