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Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Exploring AMG 510 for advanced lung cancer with KRAS G12C mutation.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a medicine called AMG 510 for people with a type of lung cancer that is very advanced or has come back. This cancer has a specific change, or mutation, in a gene called KRAS G12C. The medicine aims to stop cancer cells from growing.

Key Points:

  • Participants will take AMG 510 by mouth every day for 21 days in a cycle, and they will continue if the medicine is helping and not causing bad side effects.
  • After finishing treatment, participants will have follow-up check-ups every 3 months for 3 years if their cancer is stable, or every 6 months for 2 years if the cancer worsens.
  • Participants need to meet certain health conditions and agree to regular tests and blood samples for further research.

This study is looking for participants who have this specific KRAS G12C mutation and meet other health criteria. It's important to consider if you are able to attend regular follow-ups and if you are comfortable with the required tests and procedures before joining.

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Study details
    Lung Adenocarcinoma
    Lung Non-Small Cell Carcinoma
    Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
    Stage IV Lung Cancer AJCC v8
    Stage IVA Lung Cancer AJCC v8
    Stage IVB Lung Cancer AJCC v8

NCT04625647

SWOG Cancer Research Network

13 December 2024

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