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Dose-escalation, Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Patients with R/r NHL and R/r B-cell ALL

Safety study of Azer-cel for patients with certain blood cancers.

Recruiting
18 years and older
All
Phase 1

This study is testing a new treatment called azer-cel for adults with certain types of blood cancer: B-cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Azer-cel is a special kind of cell therapy that targets and destroys cancer cells. Patients will get the treatment through an IV (intravenous) infusion, which means it goes directly into their vein. Before receiving azer-cel, patients will have a procedure called lymphodepletion to prepare their body. The study will check if the treatment is safe and how well it works. Patients will be watched closely for two years and then followed up for up to 15 years.

  • The study involves multiple visits over a long period.
  • Participants will be closely monitored for side effects and treatment effectiveness.
  • There may be risks associated with the treatment and the procedures involved.
Study details
    Non-Hodgkin Lymphoma
    B-cell Acute Lymphoblastic Leukemia

NCT03666000

Imugene Limited

29 March 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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