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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

Exploring surgery options for high-risk retroperitoneal sarcoma.

Recruiting
18 years and older
All
Phase 3

This study is for people with a type of cancer called sarcoma. The sarcoma is in the belly area, known as retroperitoneal space. The study is looking at whether giving chemotherapy before surgery helps people live longer without the disease coming back. Chemotherapy uses strong medicine to kill cancer cells. This study is for people with two specific sarcoma types: **DDLPS (Dedifferentiated Liposarcoma)** and **LMS (Leiomyosarcoma)**. Participants will be placed in one of two groups: one group will have surgery only, while the other group will get chemotherapy followed by surgery.

Here are three key points to think about:

  • The study involves large surgery and possibly chemotherapy, which has side effects.
  • Participants need to visit for chemotherapy and check-ups, lasting several weeks.
  • Eligible participants will be at least 18 years old with high-risk sarcoma and need to give consent.

Before joining, participants should talk to their doctors about the possible benefits and risks, such as side effects from chemotherapy and surgery recovery.

Study details
    Retroperitoneal Sarcoma
    Liposarcoma
    Leiomyosarcoma

NCT04031677

European Organisation for Research and Treatment of Cancer - EORTC

29 March 2025

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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