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APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)

APOLLO: Studying kidney transplant outcomes in patients with APOL1 variants.

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Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

The APOLLO study is researching how variations in the APOL1 gene affect kidney transplant results. A gene is like a set of instructions passed from parents to children, such as for eye color. Some variations in the APOL1 gene can lead to kidney problems. People of recent African ancestry (African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans) might have these variations. This study will test DNA (genetic material in cells) from kidney donors and recipients to understand the effects on kidney transplants. The study is supported by the National Institutes of Health (NIH) and looks at both living and deceased donors. The main focus is on people with recent African ancestry, meaning they have a genetic background similar to those in Africa.

  • Time frame: Phase II started on 9/1/2023, lasting 2 years.
  • Participants: Only living donors with recent African ancestry are eligible.
  • Commitment: Participants must give blood samples and consent.
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Study details
    Kidney Diseases
    Kidney Failure
    Kidney Disease
    Chronic

NCT03615235

Wake Forest University Health Sciences

21 June 2025

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