In this clinical trial, researchers want to see how well the drug letrozole, with or without other chemotherapy drugs, works for patients with advanced low-grade serous cancer in the ovaries, fallopian tubes, or peritoneum. Letrozole helps lower estrogen levels, which can slow down cancer cell growth. Other drugs like paclitaxel and carboplatin kill cancer cells or stop them from spreading. This study will help determine if letrozole alone or with chemotherapy is more effective. Participants are randomly placed into two groups: one group takes letrozole and the other takes both letrozole and chemotherapy. This study lasts several years, with follow-up visits every few months.
- Participants will have regular follow-ups for up to 4 years.
- Participants must have had surgery to remove as much of the cancer as possible.
- Participants cannot have had previous chemotherapy or radiation for this cancer.
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