This study is looking at two ways to treat pulmonary embolism (PE). A PE is a blockage in your lungs, usually caused by blood clots. The study compares using only blood-thinning medicine (anticoagulation) with using the medicine plus a special tool called the Indigo Aspiration System to remove the clot. You can join if you are 18 to 80 years old and have an acute (recent) PE that started less than 14 days ago. To join, a special scan, called computed tomographic pulmonary angiography (CTPA), must show a clot in your lung. You cannot join if you have certain medical conditions like heart or lung issues, severe infections, or if you are pregnant.

• This study may involve treatments with blood thinners and a clot-removing tool.
• Participants need to be 18-80 years old with a recent PE.
• People with certain health conditions or recent surgeries cannot participate.