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Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Studying heart tissue changes as children grow.

Recruiting
20 years and younger
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at small pieces of human hearts removed during necessary surgery. It seeks to understand how calcium ions (tiny charged particles that help your heart beat) move in heart cells and how newborn heart cells differ from adult ones. Scientists also want to make stem cell-derived heart cells (hPSC-CMs) become more like real heart cells by using different techniques. This research helps us learn about heart cells in infants and adults and could improve treatments for heart disease.

  • Study involves using heart tissue from surgeries.
  • Focus on how newborn and adult heart cells differ.
  • Only for patients having specific heart surgeries.

Eligible participants include those having surgery for heart issues like ventricular septal defect (a hole in the heart) or valve problems. However, if you’ve had previous heart surgery or have certain heart conditions, you cannot participate. This study aims to create a better understanding of heart cell function and improve future treatments.

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Study details
    Congenital Heart Disease
    Tetralogy of Fallot

NCT00243776

Emory University

21 June 2025

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