This study is testing a medicine called Brilaroxazine, also known as RP5063, to see if it is safe and works well for people with schizophrenia. Schizophrenia is a mental illness that can make it hard to think clearly or know what is real. In the study, people will take Brilaroxazine pills once a day. First, they will take a fixed (same) dose for 4 weeks. After that, they will take a flexible dose for 52 weeks. Some people will get a placebo instead, which is a pill that doesn't have the medicine. This helps researchers see if the medicine really works.

Key Points:

• The study lasts 56 weeks in total, starting with 4 weeks of fixed doses and then 52 weeks of flexible doses.
• Participants need to be between 18 and 65 years old with a diagnosis of schizophrenia.
• People who have tried many treatments without success or have other serious health issues cannot join.