The **I-SPY Trial** is a research study designed to find the best ways to treat different types of breast cancer using new drugs before surgery. Doctors will look at how well these drugs work with standard chemotherapy. The study uses **MRI** (magnetic resonance imaging) pictures and samples of tissue and blood to see how the cancer responds to the treatment. This helps doctors predict which treatments might be successful for specific types of breast cancer.

To join the study, you must be at least 18 years old and have breast cancer that hasn't been treated with chemotherapy or radiation. You can’t have metal implants that would interfere with an MRI. You must also be willing to have a biopsy, which is when a small piece of the tumor is taken to study. You need to sign a consent form agreeing to be part of the study.

• The study involves **new drugs and standard treatment** to see which works best for different cancers.
• You need to be **at least 18 years old** and agree to have tests and biopsies.
• Participants must be **able to have an MRI** and not have certain health issues or metal implants.