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Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults

Exploring new treatments for a specific type of leukemia in adults.

Recruiting
18-75 years
All
Phase 3

This study is testing different treatments for a type of blood cancer called BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL) in adults. The researchers want to see if adding a drug called blinatumomab to the usual treatment, which includes chemotherapy, steroids (medicines that reduce inflammation), and a tyrosine kinase inhibitor (TKI, a medicine that blocks cancer growth), works better. Blinatumomab is a special medicine that helps the body's immune system attack cancer. The study will also look at how long patients live, how well the cancer is controlled, and any side effects from the treatments.

Key Points:

  • Duration: This study involves multiple cycles of 21-28 days, with follow-up visits for up to 10 years.
  • Procedures: Participants will have several tests like bone marrow biopsies and scans.
  • Eligibility: Participants must be 18-75 years old, not pregnant, and meet certain health criteria.
Study details
    B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

NCT04530565

National Cancer Institute (NCI)

3 May 2025

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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