This study is testing a medication called setmelanotide for people with obesity and special gene changes in the MC4R Pathway. The MC4R Pathway is a system in your body that helps control hunger. This study is a randomized, double-blind, placebo-controlled trial, which means some people will get the real medicine, and others will get a fake one, but no one will know which one they're getting. You can join if you're between 6 and 65 years old, have obesity, and have one of the specific gene changes listed. You should not join if you have certain health problems or had recent weight loss surgery.

• The study involves several visits to the clinic over a period of time.
• Participants must agree to use contraception and report any lifestyle changes.
• Some people may not be able to join, like those with major health issues or those who are pregnant.