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A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Research on new treatments for recurrent low-grade ovarian cancer.

Recruiting
18 years and older
Female
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for women with recurrent Low-Grade Serous Ovarian Cancer (LGSOC), a type of cancer that affects the ovaries. Researchers want to see if two experimental drugs, avutometinib and defactinib, work better than standard treatments. These drugs are called kinase inhibitors, which help stop cancer cells from growing. The study will check how long the treatment can keep the cancer from getting worse and see how safe it is for patients. If you join, you will either receive the new drug combo or one of the standard treatments. If the standard treatment doesn't work, you might switch to the new drug combo.

  • Study Length: Participation involves several visits and follow-ups.
  • Eligibility: Must have LGSOC, previous treatment, and meet other health requirements.
  • Compensation: No mention of payment; focus is on treatment and monitoring.
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Study details
    Low Grade Serous Ovarian Cancer

NCT06072781

Verastem, Inc.

30 August 2025

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