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Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

Testing Nivolumab with Ipilimumab for specific endometrial cancer type.

Recruiting
18 years and older
Female
Phase 2

This research study is for patients with a type of cancer called recurrent endometrial carcinoma, which has a problem in its DNA repair system, known as deficient mismatch repair system (dMMR). The study wants to see if two medicines, nivolumab and ipilimumab, can help better than nivolumab alone. These medicines are monoclonal antibodies, which help the immune system fight cancer.

In this study, some patients will get both medicines, while others will get just one. The study will check if tumors shrink or stop growing. It will also see how well patients live while on these treatments. To join, patients need a certain type of endometrial cancer and should have recovered from recent treatments.

  • Study Duration: Patients are followed for up to 5 years.
  • Treatment Visits: Every 3-4 weeks initially, then less often.
  • Risks: Possible side effects from medications; frequent health checks needed.

Participants must be over 18, not pregnant, and should use contraception if of childbearing age. It's important to discuss with a doctor before joining to understand all details and eligibility requirements.

Study details
    Endometrial Adenocarcinoma
    Endometrial Clear Cell Adenocarcinoma
    Endometrial Dedifferentiated Carcinoma
    Endometrial Endometrioid Adenocarcinoma
    Endometrial Mixed Cell Adenocarcinoma
    Endometrial Mucinous Adenocarcinoma
    Endometrial Undifferentiated Carcinoma
    Endometrioid Adenocarcinoma
    Recurrent Endometrial Carcinoma

NCT05112601

National Cancer Institute (NCI)

16 March 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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